5/3/2023 0 Comments Delta phenomenon dates![]() Increases in bilirubin levels can result from prehepatic, hepatic, and/or posthepatic conditions, making fractionation useful in determining the cause of the increase in total bilirubin levels. Defects in bilirubin excretion can be identified in a routine urinalysis. In the small intestine, conjugated bilirubin converts to urobilinogen and then to urobilin. Unconjugated bilirubin is carried to the liver by albumin, where it becomes conjugated. Total bilirubin is the sum of unconjugated or indirect bilirubin, monoglucuronide and diglucuronide, conjugated or direct bilirubin, and albumin-bound delta bilirubin. Bilirubin is primarily produced in the liver, spleen, and bone marrow. Values in premature infants may initially be higher than in full-term infants and also take longer to decrease to normal levels.ĭescriptionBilirubin is a by-product of heme catabolism from aged red blood cells (RBCs). Values in breastfed infants may take longer to reach normal adult levels. Normal findings(Method: Spectrophotometry) Total bilirubin levels in infants should decrease to adult levels by day 10 as the development of the hepatic circulatory system matures. Plasma (1 mL) collected in green-top (heparin) tube or in a heparinized microtainer is also acceptable. ![]() SpecimenSerum (1 mL) collected in gold-, red-, or red/gray-top tube. A multipurpose lab test that acts as an indicator for various diseases of the liver or for disease that affects the liver. ![]()
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